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Gallbladder issues can occur because Mounjaro reduces the amount of a hormone the body makes called cholecystokinin, which helps the gall bladder function effectively

The drug functions as a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

Additionally, tirzepatide is not recommended for patients with severe gastrointestinal disease, including severe gastroparesis