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Diagnosis can be made through hormonal and imaging tests, and treatment typically involves subcutaneous injections of synthetic GH replacement therapy to stimulate growth ( Sleep is an important period of increased GH release ( This narrative review (incorporating a systematic search of the literature) aimed to assess the relationship between GH and sleep in children, and assess the impact of GH therapy on sleep quality in children with idiopathic GHD ( Figure 1 )

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Under high-glucose conditions, the expression of TREM1 is upregulated, activating the PERK pathway (69)