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Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial
After ruling out the pharmaceutical issues above, consider whether biological factors are limiting your response
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This test evaluates key variants such as GLP1R rs6923761, which affects how sensitively your GLP-1 receptors respond to semaglutide
Additionally, over-the-counter medications and herbal supplements should only be used after consulting with a healthcare provider, as some substances may interact negatively with tirzepatide
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