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In addition, green tea polyphenols can activate AMP-activated protein kinase in the liver, skeletal muscle, and adipose tissues and thereby can induce substrate oxidation (Reference Yang, Zhang and Zhang51)

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Beyond neurological implications, the research extends to oncology, particularly tumors harboring mutations in the KEAP1 gene

Metabolites 2022 , 12 , 205 [11] Ismail, A.M

Now we dont know if itll extend lifespan, but it does seem to do the same kind of things that metformin does, and metformin seems to have all the hallmarks of a lifespan-extending drug, so I think berberine is a good option. Sinclair notes one thing to consider: Berberine is also insoluble, so he suggests mixing it into yogurt or oil for better absorption and reduced side effects