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These beneficial effects may be due to the formation of detour circuitswhich encompass spared tissue surrounding the lesionand could reconnect locomotor circuits [69], thus enabling afferent inputs to be processed and conveyed to the cortex [73] and improving spinal reflexes, even below the injury [74]

The level of iron ions in the glomerulus of mice in the model group was significantly higher than that in the control group, whereas the iron ion level in the RGSH group was significantly lower than that in the AKI model group

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Mechanisms proposed in the literature Several cellular pathways have been proposed to explain BPC-157's preclinical effects

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