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Two studies from Seoul National University (Republic of Korea) found the effects of GHK-Cu and GHK copper-free on cell differentiation on a skin equivalent cell culture system produced identical results

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The copper ion is not merely a passenger in this complex it is integral to the peptide's biological activity, as GHK without copper shows significantly diminished effects in many assays

Further analysis also revealed a difference in variance in HIF1a + Tbr2 + co-labeled INPs (Fig