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2013;5:3546-683 Definitions Metabolism - a biochemical transformation Observational study - a human research study in which no experimental intervention or treatment is applied, and participants are simply observed over time Placebo - a chemically inactive substance Randomized controlled trial - a human research study in which participants are assigned by chance alone to receive either an experimental agent (the treatment group) or a placebo (the control group) Venous thrombosis - a blood clot that forms in a vein Authors and Reviewers Originally written in May 2015 by: Giana Angelo, Ph.D

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High insulin stimulates certain growth factors in the skin, leading to thickening of the outer skin layer and increased pigmentation

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