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The thicker skin of palms and soles presents additional delivery challenges that may require enhanced penetration strategies

The scans also detected nodules on her thyroid, which have yet to be biopsied

Limited Human Data Human research involving these peptides is: small-scale narrowly focused not designed to establish long-term safety insufficient for determining risk in broader contexts As a result, long-term biological effects remain unknown

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Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: April 5, 2026 The short answer is that long-term Melanotan use carries significant uncertainties because the synthetic peptide is not FDA-approved, and no rigorous clinical trials have studied its extended safety profile