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The most common any-grade imAE categories (2.0% of participants) in the STRIDE arm were endocrine events (16.5%, including hyperthyroid events, hypophysitis, and hypothyroid events), hepatic events (7.5%), diarrhea/colitis (5.9%), dermatitis/rash (4.9%), and pancreatic events (2.3%) (Supplemental Table S2, Hepatic events and endocrine events were the most common any-grade imAE categories (2.0% of participants) in the durvalumab monotherapy arm, occurring in 6.7% and 6.2% of participants, respectively (Supplemental Table S2, Across the STRIDE and durvalumab arms, the proportions of participants who had a hepatic imAE that resolved, or led to discontinuation of study drug, or did not resolve were similar (Supplemental Table S3, The most common any-grade imAEs (2.0% of participants) in the STRIDE arm were hypothyroidism (10.1%), hyperthyroidism (4.6%), diarrhea (4.4%), hepatitis (2.6%), rash (2.3%), and alanine aminotransferase increase (2.1%) (Figure 2)

It is characterized by hyperandrogenism, oligo/anovulation, and polycystic ovarian morphology, often accompanied by insulin resistance, dyslipidemia, and low-grade chronic inflammation

Understanding the influence of dietary habits on autoimmune disorders has become increasingly critical, as the global prevalence of these conditions continues to rise and curative treatments remain limited

10.1016/j.neuropharm.2014.04.007 [DOI] [PubMed] [Google Scholar] 34.Pang J, Feng JN, Ling W, Jin T (2022) The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs-therapeutic potential exploration in lung injury

Even if the FDAs committee recommends in favor of peptides this week, its unclear what the timing would be for their ultimate approval