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In the realm of reproduction, appropriate levels of autophagy are crucial for oocyte development and maturation, as well as for preventing endometrial metaplasia ( 3 Impact of metformin on different stages of polycystic ovary syndrome 3.1 Impact of metformin on adolescent patients with polycystic ovary syndrome The prevalence of adolescent PCOS has shown a notable increase in recent years

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McCoy and colleagues reported that 5-day treatment of dissociated rat hippocampal neurons with Dihexa increased dendritic spine density approximately three-fold compared to vehicle control (~41 spines per 50 m of dendrite versus ~15 spines), with the increase reflecting both new spine formation and increased spine-head width consistent with synaptic maturation [2]

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