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7 nicotinic acetylcholine receptors (7nAChR) are key receptors for inhibiting inflammation in the cholinergic anti-inflammatory pathway, and there is a correlation between them and RA, while sinomenine can inhibit the expression of 7nAChR and exert anti-inflammatory and anti-arthritis effects through ERK/Egr-1 signaling pathway transduction (68, 69)

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