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GLP-1R signaling in the brain exerts antidepressive effects by improving cognitive processes, promoting neuroprotection and neurotransmitter release Patients suffering from depression are characterized by impaired neuronal activity and synaptic plasticity dysfunction, resulting in volumetric changes in brain regions which regulate emotions or the stress response such as the hippocampus and the prefrontal cortex

Economic Costs of Diabetes in the U.S

doi: 10.1111/dom.14226

Seek immediate emergency care for chest pain lasting more than a few minutes, pain radiating to the arm, jaw, neck, or back, or chest discomfort accompanied by shortness of breath, sweating, nausea, or lightheadedness

Patients interested in emerging options can review comparisons like Ozempic versus retatrutide to understand how next-generation compounds might eventually expand the available choices