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The DCCT study demonstrated that intensive insulin therapy in T1D significantly reduced the risk of DPN by 64% and cardiovascular autonomic neuropathy by 45% compared with conventional treatment, with these benefits persisting for over 13 years after the trial ended [60]

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That success has been driven largely by GLP-1 therapies such as semaglutide and tirzepatide, developed by Novo Nordisk and Eli Lilly

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