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doi: 10.1038/s41586-019-1705-2 94 GuoXLiuFDengJDaiPQinYLiZet al
The cDNA of this variant was cloned from active muscle and characterized as an autocrine factor that is, one that acts on or near the cell that produces it distinguished from the liver-derived, endocrine IGF-1 that has a systemic mode of action
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Promotes formation of new adhesions allowing cell anchoring to matrix during forward movement
When vitamin C deficiency or metabolic disorders are suspected
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