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For disrupting tumor glucose metabolism, nanomaterials share merits in active targeting via surface modifications, improving drug accumulation within the tumor, on-demand drug release through stimuli-responsive designs according to endogenous stimulating signals, such as pH, ROS, and enzymes, and multifunctionality integrating diagnostics with combination therapies [33,34,35]
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In addition, H2O2 may activate transcription by directly oxidising H2O2-responsive transcription factors via oxidation of thiols of cysteine residues in protein
