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They are produced by different types of cells and, once released in the body, induce specific reactions in adjacent cells (paracrine effect), in others far away (endocrine effect) or in those that have created them (autocrine effect)

Cozmin M, Lungu II, Gutu C, Stefanache A, Duceac LD, oltuzu BD, et al

According to Zahiri et al

The proinflammatory mitochondrial phenotype is related to mtDNA mutation and decreased oxygen partial pressure in the synovium (Du et al., 2020), suggesting that hypoxia and oxidative stress may play a significant role in causing joint inflammation

10.1074/jbc.M114.635144 24 Cubillos-RuizJ