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Understanding these mechanisms is essential for interpreting the breadth of effects reported across preclinical studies

Here, we provide the first evidence of improved healthspan and age-related survival with a therapeutic mAb by demonstrating that treatment with an IGF-1R antagonist in older mice significantly and preferentially improves several indices of healthspan, reduced death from neoplastic disease, and increased mean and median lifespan in females

The S100 proteins are expressed in a cell- and tissue-specific manner and engaged in multiple functions in various cell types and tissues ( The S100 protein is the largest subgroup within the superfamily of calcium-binding EF-hand motif

(Berlin: Springer), 137152

PubMed Central, Matsunaga, Tetsuro, et al