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Sensitivity landmark analyses stratified by timeframe of semaglutide initiation Given that semaglutide was initially approved for type 2 diabetes, with initial obesity approval in 2021, it is possible that inclusion of non-diabetic patients could introduce indication bias in the previously described analyses, as non-diabetic patients enrolled before 2021 likely represent off-label use and may differ systematically from those treated after approval

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Injecting too shallow (intradermal injection) The opposite problem of going too deep is not going deep enough

Insufficient treatment duration represents a frequent issue

There is no direct pharmacokinetic drug interaction between alcohol and tirzepatide listed in FDA prescribing information