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In 2012, WADA placed tramadol on its monitoring programme, which includes substances that arent on the prohibited list but are becoming increasingly popular and may have performance enhancing effect or endanger health

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Besides, HIF-1 expression affects articular cartilage degeneration in OA by affecting metabolic stress, oxidative stress, the levels of ROS and ECM gene, chondrocyte activity, and inflammatory response (85)

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