glp 1 ra black box warning Glp1 and thyroid anomalies? : r/FamilyMedicine TGA issues warning over GLP-1-based

In a cardiovascular outcomes trial of liraglutide 1.8 mg, weight loss was sustained over a median trial period of 3.5 years in patients with type 2 diabetes who had either cardiovascular disease or risk factors for cardiovascular disease [60]

Egecioglu E, Engel JA, Jerlhag E

doi: 10.1016/S2213-8587(24)00058-5

Moreover, differences in outcome reporting, such as the use of absolute versus relative changes, or inconsistent definitions of endpoints like visceral adiposity or insulin resistance, further limited the ability to standardize data extraction and synthesis

During diabetes progression, the brains reliance on mitochondria makes it more vulnerable to oxidative damage compared to other regions