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However, while many drugs have been synthesized to target glutamine metabolism from its initial transport into the cell to its conversion to -KG, most are still in preclinical stages (Table 1) [44]

As a result, oxyThDP inhibits ThDP-dependent dehydrogenases, whose function is required for ACh synthesis, particularly pyruvate dehydrogenase complex generating ACh precursor acetyl-CoA (Figure 1)