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In DKD, ERS is primarily triggered by hyperglycemia, proteinuria, and the presence of AGEs and free fatty acids ( A recent study has revealed that ERS can increase the levels of unsaturated triacylglycerol precursors and reduce lipid droplet formation, leading to tubular injury and fibrosis in renal proximal tubular cell lines and STZ-induced diabetic mouse kidneys ( Several studies have demonstrated the beneficial effects of various inhibitors targeting ERS in DKD

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Glutathione 1200 mg injections are used as an antioxidant for treating liver diseases and are popularly used in cosmetic dermatology for skin brightening

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