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At the same time, pro-inflammatory factors (TNF- and IL-1) were downregulated and anti-inflammatory factors (Arg-1 and IL-10) were upregulated due to SIN produced through the NF-B pathway, which decreased M1 macrophage levels and increased M2 macrophage levels

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Khalil M, Shanmugam H, Abdallah H, John Britto JS, Galerati I, Gmez-Ambrosi J, Frhbeck G, Portincasa P (2022) The potential of the Mediterranean Diet to improve mitochondrial function in experimental models of obesity and metabolic syndrome