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Patients need to know how the medication is handled, how injections are administered if applicable, how follow-up is performed, what dietary instructions must be followed, and what warning signs require medical attention

Therefore, developing advanced drug delivery systems, such as bilirubin nanomedicines, represents a critical direction for the future clinical translation of bilirubin-based therapies (Lee et al., 2016)

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Upon the onset of oxidative stress, two GSH molecules are oxidized to glutathione disulphide (GSSG), which can be reversibly reduced to GSH by GSSG reductase 35