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This variability complicates the ability to draw detailed conclusions about the cell types and behavior based on scRNA-seq data

The oscillation activation of PARP-1 interacts with and poly(ADP-ribosyl)ates CLOCK, leading to suppressed binding of CLOCK: BMAL1 to DNA and altered circadian gene expression

Despite numerous clinical and preclinical investigations, there is lack of studies that have utilized fascicle- or fiber- specific stimulation that can even further potentiate the therapeutic efficacy

Much has changed since 2020, but much has not