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Only one significant change was noted in the Caco2 cell linea 12% increase in the level of sulfane sulfur-containing compounds after the addition of DMSO-loaded (3%) polymerosomes to the serum-free medium (Table 1)

Dehydration reduces blood volume by as little as 2%, causing dizziness when standing and making breathing feel labored during normal activities

SAGE Journals+1 Safety (preclinical): multi-species toxicology work (mice, rats, rabbits, dogs) reported good tolerability at tested doses

Clinical research suggested doses in the range of 1-10mcg per kilogram of body weight showed efficacy, though most protocols standardized around 4-6mcg/kg for practical application