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The sequestration of cystine within lysosomes may deplete cytosolic cysteine, which is essential for glutathione synthesis, leading to impaired redox homeostasis [144, 146]

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Healthy mesenchymal stem cell-derived exosomes (MSC-Exo) safeguard chondrocytes against TNF-induced apoptosis through the delivery of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), thereby retarding joint destruction [39]

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Glutathione is so impactful to human health that it has been dubbed the mother of all antioxidants. Concentrations of glutathione are especially high in the liver, playing a protective role for hepatocytes, erythrocytes, and other cells against toxicity