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TIER PLANS TIER 0 (20mg total) $295 total for 10 week supply Monthly cost breakdown: $118 Recommended if using low (or micro) doses of 2mg/week or less TIER 1 (40mg total) $350 total for 8-10 week supply Monthly cost breakdown: $140-$175 based on weekly dose Recommended if new to treatment or for those on 2-5mg/week TIER 2 (60mg total) $395 total for 8-10 week supply Monthly cost breakdown: $158-$197 based on weekly dose Recommended for those on 6-7mg/week TIER 3 (80mg total) $495 total for 8-10 week supply Monthly cost breakdown: $198-$247 based on weekly dose Recommended for those on 8-10mg/week TIER 4 (120mg total) $645 total for 8-10 week supply Monthly cost breakdown: $258-$322 based on weekly dose Recommended for those on 11mg/week and up MONTHLY PLANS Monthly Starter Dose $175 total for one month supply Recommended if new to treatment or for those on doses of 2.5mg/week or less Monthly Mid Dose $245 total for one month supply Recommended for doses up to 7.5mg/week Monthly Advanced Dose $275 total for one month supply Recommended for doses of 7.5-10mg/week Monthly Advanced Plus Dose $335 total for one month supply Recommended for doses of 11mg/week and up OptioRX Pharmacy - Tirzepatide/Niacinamide Injection Up to 90 days BUD

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Given the difficulty in quantifying upper motor neuron dysfunction on clinical exam alone, some studies have used transcranial magnetic stimulation (TMS) to indirectly measure cortical hyperexcitability as a surrogate for pyramidal cell dysfunction

Apoptosis 29(34):289302 Jiayi H et al (2024) Copper homeostasis in chronic kidney disease and its crosstalk with ferroptosis

doi: 10.1093/ije/dyw115