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[21] Testosterone-containing variants are strictly contraindicated in pregnancy (category X) because virilization of a female fetus can occur with even minimal systemic absorption

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263,264 For example, tryptanthrin, a natural product, inhibits glutathione S-transferase P1 activity and promotes primary senescence of hepatocellular carcinoma cells

Even with this technology, only a small portion of the medication is absorbed, which is why the pill uses higher doses than the injectable form