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Some anesthesiologists are now choosing to avoid nitrous oxide usage in individuals with known MTHFR mutations (19) and instead utilize other inhaled anesthetics such as sevoflurane

doi: 10.1016/j.omto.2017.05.005 108 PawlikTMNakamuraHMullenJTKasuyaHYoonSSChandrasekharSet al

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Some major drawbacks associated with the clinical application of such NPs are their poor ability to cross the BBB and the inconsistent clinical efficacy of GDNF in PD treatment