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A noticeable decline in control over your blood sugar levels might indicate your semaglutide has gone bad and is no longer effective

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As mentioned above, after observing incidental weight loss in drug trials of Ozempic, the same pharmaceutical company, Novo Nordisk, went on to develop Wegovy, a weight-loss version of Ozempic

But for a subset of patients, those who are particularly sensitive to GLP-1 effects on the gastrointestinal tract, even this modest fluctuation is enough to cause problems during the peak phase

Kevin Jones, MD, Board-Certified Obesity Medicine Physician, Medical Director, Flow Wellness Last updated: July 2026 Lets be honestGLP-1 shots like tirzepatide can do great things for your health, but figuring out your dose can be confusing