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There was no increase in serious cardiovascular events during 68 weeks of treatment (including follow-up)

This is the kind of area where headlines tend to run ahead of the science

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MR analysis indicated that genetically proxied GLP-1RAs were associated with a reduced risk of AF (odds ratio [OR] = 0.78, 95% confidence interval [CI] = 0.710.85, p = 4.45E-08, posterior probability of hypothesis 4 [PP.H4] = 0.007) and a lower risk of cardiac arrest and ventricular fibrillation (OR = 0.60, 95% CI = 0.420.85, p = 0.0039, PP.H4 = 0.018)

Omarigliptin accommodates in S 1 active subsite where it binds with several hydrophobic residues like Tyr666, Val711, and Tyr662