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The authors reported that the combination was generally tolerated across the tested levels, with adverse events predominantly gastrointestinal and graded mild to moderate, and that the pharmacokinetic profile was consistent with once-weekly administration in the trial design

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Based on these, LMW-DS has been used in inhibition of IBMIR in animal models and patients of islet transplantation (von Zur-Mhlen et al., 2019

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(4) Polyphenols: Rhein, as one of the main components of rhubarb, has been proven to possess antibacterial and antioxidant effects