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During stressful periods Stress generates free radicals and depletes antioxidant stores rapidly
Evidence for separate roles Several lines of evidence support the notion of distinct roles for peripheral and central GLP-1 in appetite regulation: Differential breakdown: Peripheral GLP-1 has a very short half-life in the blood (around two minutes) due to enzymatic degradation
Safety Considerations and Who Should Start GLP-1 Therapy GLP-1 agonists are contraindicated in personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2
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