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At week 4, women in the treatment group displayed improved skin elasticity (+12.7%), reduced wrinkle volume (16.5%), decreased transepidermal water loss (10.8%), increased hydration (+3.5%), and enhanced collagen density compared with baseline values (measured via specialized skin analysis instrumentation)

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10.1172/jci65566 J

Therefore, delphinidin faces a fundamental challenge posed by the substantial gap between its effective in vitro concentrations and actual in vivo exposure levels