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Exposure of neonatal rat cochlear explants to various doses of cisplatin or aminoglycosides, including but not limited to gentamicin, neomycin, kanamycin and tobramycin, ranging from 5-200 M for periods of 12 to 48 hours will induce varying degrees of cochlear hair cell death as well as spiral ganglion neuron (SGN) damage

Vitamin B-12 is the largest and most structurally complicated vitamin

Primary Mechanisms: Telomere vs Matrix Biology Epitalons core dermal anti-ageing mechanism is telomerase (hTERT) activation: TRAP assay (telomere repeat amplification protocol) a PCR-based measurement of telomerase activity in cell extracts shows dose-dependent telomerase activation in human dermal fibroblasts (HDFs) after Epitalon treatment (0.110 nM, 24h)

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