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Despite lower efficacy and tolerability shown by nasally administered PYY agonists in early studies, long-acting subcutaneous PYY receptor agonists such as PYY 1875 are undergoing early-phase clinical trials to evaluate their safety and effectiveness as monotherapy or in combination with GLP-1 receptor agonists for the treatment of obesity
Nearly half of Americans are living with obesity, which is associated with more than 200 related health issues and diseases, including type 2 diabetes
doi:10.2337/diabetes.53.8.2079 110
Mascitelli L, Pezzetta F, Sullivan JL
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