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Weeks 916 Many patients reach 15 pounds lost Both medications are effective

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It should be noted that while GLP-1 agonists positively impact metabolism upstream of the liver, this may not subsequently improve the fibrotic liver injury within the tested treatment duration

[39] One major limitation in the use of GLP-1 peptide was its extremely short half-life (1.55 minutes) due to rapid cleavage and degradation by the enzyme dipeptidyl peptidase-4 (DPP-4), [40] so DPP-4 resistant GLP-1 RAs were developed for longer-lasting effects

In the ACHIEVE3 trial, orforglipron demonstrated greater A1c reduction than oral semaglutide in patients with type 2 diabetes (2.2% vs