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In contrast, intragastric infusion of lipids, glucose, and amino acids all robustly suppresses the activity of ARC AgRP/NPY neurons as does systemic administration of CCK and PYY 336 [148, 149]

[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Wan F.J., Tung C.S., Shiah I.S., Lin H.C

Although the exemplified procedures herein illustrate the practice of the present invention in some of its embodiments, the procedures should not be construed as limiting the scope of the invention

Significant weight loss outcomes in Phase 2 (up to 24.2% at 12mg over 48 weeks) were recorded at higher doses