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Methods A total of 147 women with PCOS were randomly assigned into two groups: the combo group ( n = 72) received a combination of metformin, pioglitazone, and ALC (500 mg, 15 mg, and 1500 mg, respectively), twice daily

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Since levels of hippocampal neurochemicals did not differ between Sham + NS and Sham + ALCAR, we combined these groups for subsequent comparison between TBI + NS and TBI + ALCAR while analyzing regional differences (ipsilateral vs contralateral hippocampi)

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