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While the male longevity was not affected by the cIII or cV knockdown, females with cIII knockdown exhibited significantly decreased lifespan (Additional File 3: Fig

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This was further associated with reductions in hepatic expression of sterol regulatory element binding protein (SREBP)-1c and elevated LDL receptor expression, which occurred independent of food consumption [94]

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133 , jcs251819 (2020)

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