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3) REST: Upregulated in AKI (104), suppresses glutamate-cystine ligase modifier subunit (GCLM) transcription, reducing GSH/GPX4 to promote lipid peroxidation/ferroptosis

The effect of ASX on NO, which plays a key role in vascular tonicity and arterial blood pressure-mediated vasorelaxation, has been explored [26,34]

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Precision targeting of the CNS: recent progress in brain-directed nanodrug delivery

The IVR domain contains a 3-box motif in its proximal part, which provides an additional CUL3 interaction site [116], and two critical cysteine residues, Cysteine273 (C273) and Cysteine288 (C288), that are important for the repression of NRF2 activity [126]