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Downregulation of ATP5A1, the ATP Synthase F1 Subunit Alpha [123], and ATP5G3, the ATP synthase F0 complex subunit C3 [124], was observed in the postmortem study of ASD patients in all examined regions [122], which could inhibit the activity of complex V [79] and promote the ETC breakdown due to opening of the mPTP [125, 126]

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The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients

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Some of the symptoms from toxicity in general and mycotoxins specifically that can occur in individuals who have a genetic methylation defect may include the following symptoms: Chronic fatigue