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However, a small percentage (~10-20%) of individuals are unlikely to respond well to the medication for various reasons

Neefs J, van den Berg NWE, Krul SPJ, Boekholdt SM, de Groot JR (2020) Effect of spironolactone on atrial fibrillation in patients with heart failure with preserved ejection fraction: post-hoc analysis of the randomized, placebo-controlled TOPCAT trial, (in eng)

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Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial

NAC capsules provide precise dosing, are easy to transport, and avoid the taste issues associated with powder