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Over time, researchers discovered additional benefits beyond glucose management

10.1016/s0047-6374(01)00225-1 6 BalanE.DecottigniesA.DeldicqueL

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These cytokines also contribute to IR through mechanisms including inhibitory phosphorylation of insulin receptor substrate-1 (IRS-1) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) pathway, while also promoting glucocorticoid resistance and HPA axis hyperactivity [80]

Minimal immune responses to the TPT API peptide were observed in T-cell assays performed with multiple donor PBMC samples, when considering both the percentage of responsive PBMC donors and the magnitude of the IFN- cytokine response, as was also observed for the Forteo drug product