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SpyCatcher003-mi3 nanoparticles that display RBDs from both human and animal coronaviruses were prepared to evaluate the effectiveness of mosaic particles in producing cross-reactive antibody responses (Table 2)

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ECG Recording ECGs were recorded continuously in deeply anesthetized rats for all three main leads, by positioning stainless steel electrodes on all four limbs using an ECG monitor with a 2090 programmer (Medtronic, United States) connected to a Waverunner LT342 digital oscilloscope (LeCroy, United States) at 30 min ligation time