Taken together, the figure highlights a key mechanistic principle underlying the therapeutic rationale for multi-agonist strategies: while GLP-1R monotherapy achieves meaningful metabolic and hepatic benefits exclusively through indirect, systemic pathways, the addition of GIPR and - most importantly - GCGR co-agonism introduces complementary and increasingly direct hepatic mechanisms, providing the pharmacological basis for the superior efficacy observed with dual and triple agonists in MASLD/MASH
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It plays an important role in cellular energy production and the maintenance of keratin infrastructure
During treatment, seek urgent medical advice if you develop severe stomach pain, signs of gallbladder problems, or symptoms of an allergic reaction such as swelling of the face, lips, or throat
