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Neurological research has explored its effects in models of traumatic brain injury and spinal cord compression, with several studies reporting improved functional recovery versus vehicle controls

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There are concerns about adherence to oral treatment, for example, if the person: Is older, is or has recently been in hospital and has either multimorbidity or frailty

Myeloproliferative neoplasms (such as polycythaemia vera or chronic myeloid leukaemia) and acute leukaemias can increase B12-binding proteins (transcobalamins), raising total serum B12