doi: 10.1001/jama.286.24.3083 135 LunemannJDTintoreMMessmerBStrowigTRoviraAPerkalHet al
It belongs to a novel class of drugs known as triple agonists, meaning it simultaneously activates three hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors
The efflux mechanism is counteracted by thiopurine cellular circulation , whereby thiopurine nucleotides extruded by ABCC4 will be salvaged by an extracellular enzyme NT5E through hydrolysis into nucleosides, before being transported back into the cells by nucleoside transporters (Li et al., 2010)
Health professionals recommend taking it 30 minutes before eating, drinking, or taking any other medicine, to allow the pill to take effect
Adjustable intragastric balloon for treatment of obesity: a multicentre, open-label, randomised clinical trial