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Tirzepatide: Dual-Receptor Therapy Through GIP and GLP-1 Tirzepatide is different from semaglutide because it activates two hormone-related pathways: GIP and GLP-1

These two effects are what make the drug so useful for weight loss but they are also the reason why some people experience digestive discomfort, especially in the early weeks

It lacks the significant anti-inflammatory properties found in NSAIDs like ibuprofen, which work peripherally to inhibit COX enzymes and reduce swelling

So, while tirzepatide is also a GIP receptor agonist, they have many of the same side effects

During the rapid weight loss phase, her periods actually got MORE irregular, which freaked her out